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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 18;12(2):200–209. doi: 10.1038/nn.2257

Figure 2.

Figure 2

Social isolation and imipramine modulate CREB activity in the NAcSh. (a) CRE-mediated transcriptional activity in the NAcSh of CRE-LacZ mice was decreased in group-housed animals after chronic imipramine administration (CON/IMI) (intraperitoneal injection, 10 mg per kg) and in animals after chronic social isolation (SI/CON) compared with group-housed control animals (CON/CON). Notably, chronic administration of imipramine in socially isolated animals (SI/IMI) corrected their deficit of CRE-activity compared with SI/CON animals (significant interaction of drug and housing: F1,23 = 23.94, P < 0.001, * indicates significantly different (P < 0.05) from CON/CON). (b) Representative photomicrographs of β-galactosidase immunoreactivity (that is, CRE activity).