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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 18;12(2):200–209. doi: 10.1038/nn.2257

Figure 3.

Figure 3

Increasing CREB activity in NAcSh of socially isolated animals reverses the anxiety-like behavior, but not the reward-related deficits, induced by social isolation. (a,b) AAV-mediated overexpression of CREB in the NAcSh decreased anxiety-like behavior in isolated animals on the elevated plus maze (significant main effect of housing F1,52 = 4.54, P < 0.05, significant difference between SI/GFP and SI/CREB, n = 9–17 animals per group; a), and social isolation significantly increased initiation of sexual behavior and CREB overexpression in the nucleus accumbens reversed this deficit (significant main effect of virus, F1,35 = 4.6, P < 0.05; significant main effect of housing, F1,36 = 8.02, P < 0.01; significant interaction of virus and housing, F1,36 = 6.90, P < 0.05, n = 8–11 animals per group; b). (c,d) However, CREB overexpression did not affect the deficit in the ejaculation latency (significant effect of housing, F1,33 = 37.30, P < 0.001; no significant interaction, n.s., n = 8–11; c) or sucrose intake (1% sucrose solution) (P > 0.13, n = 13; d). Conversely, CREB overexpression in grouped-housed animals (CON) significantly decreased sucrose intake (CON/GFP versus CON/CREB;* indicates P < 0.05, n = 4).