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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 18;12(2):200–209. doi: 10.1038/nn.2257

Figure 4.

Figure 4

Patterns of gene regulation in the NAcSh of socially isolated versus double-housed animals. (a,b) The pattern of genes that were upregulated (blue, a) or downregulated (yellow, b) by CREB observed in double-housed animals with CREB overexpression in the NAcSh was generally opposite to that seen in double-housed animals with imipramine (neutral on nonregulated genes appear black). (c) The pattern of gene upregulation following protracted social isolation was only partially reversed with CREB overexpression, whereas chronic imipramine treatment induced a more complete reversal of the gene expression changes caused by social isolation.