Table 1.
Examples of genes regulated in rat NAc by social isolation, CREB or imipramine
| SI/CON versus CON/CON | SI/CREB versus SI/GFP | SI/IMI versus SI/CON | ||||||
|---|---|---|---|---|---|---|---|---|
| UP (279) | UP (35) | UP (25) | ||||||
| Gene | P value | Fold Δ | Gene | P value | Fold Δ | Gene | P value | Fold Δ |
| Atf2 | 0.021 | 1.235 | Grm8 | 0.040 | 1.555 | Ppp1r15b | 0.043 | 1.896 |
| Adra2c | 0.009 | 1.325 | Cacng5 | 0.040 | 1.331 | Gsr | 0.025 | 1.439 |
| Camk1 | 0.033 | 1.310 | Neuroregulin2 | 0.031 | 1.348 | |||
| Camk4 | 0.001 | 1.368 | DOWN (471) | Spata7 | 0.041 | 1.319 | ||
| Clcn3 | 0.004 | 1.239 | Prkch | 0.014 | 1.300 | |||
| Csnk1e | 0.041 | 1.394 | Nts | 0.014 | 1.830 | DOWN (125) | ||
| Hdac4 | 0.014 | 1.349 | Ache | 0.023 | 1.396 | Map3k10 | 0.037 | 1.670 |
| Jak2 | 0.005 | 1.238 | Vamp2 | 0.017 | 1.556 | Map3k3 | 0.025 | 1.397 |
| Kcna1 | 0.044 | 1.261 | Kcnc3 | 0.037 | 2.290 | Grinl1a | 0.015 | 1.376 |
| Kcnj4 | 0.017 | 1.283 | Cacna1a | 0.012 | 1.370 | Gria2 | 0.047 | 1.324 |
| Kcnma1 | 0.027 | 1.245 | Gabrg3 | 0.042 | 1.496 | Dgka | 0.024 | 1.417 |
| Kcnd2 | 0.021 | 1.247 | Histone H2a | 0.045 | 1.755 | Gpr48 | 0.016 | 1.316 |
| Kcnd3 | 0.028 | 1.246 | Hdac10 | 0.0002 | 1.339 | Bhlhb9 | 0.015 | 1.359 |
| Kcns2 | 0.032 | 1.231 | Smarca4 | 0.021 | 1.419 | Bmpr1a | 0.025 | 1.684 |
| Kcnq3 | 0.042 | 1.362 | Hsf1 | 0.024 | 1.431 | |||
| Prkch | 0.050 | 1.284 | Grina | 0.039 | 1.305 | |||
| Smarca2 | 0.048 | 1.296 | Grin2b | 0.008 | 1.305 | |||
| Comtd | 0.038 | 1.480 | ||||||
| DOWN (3) | Cart | 0.024 | 1.495 | |||||
| Cdc2l5 | 0.004 | 1.900 | Vgf | 0.034 | 1.650 | |||
| Ppp3r2 | 0.038 | 1.502 | Gpr88 | 0.031 | 1.538 | |||
| Nnat | 0.004 | 1.294 | Il13ra1 | 0.042 | 1.382 | |||
| CON/CREB versus CON/GFP | CON/CREB versus CON/GFP | CON/IMI versus CON/CON | ||||||
|
| ||||||||
| UP (69) | DOWN (continued) | UP (144) | ||||||
| Gene | P value | Fold Δ | Gene | P value | Fold Δ | Gene | P value | Fold Δ |
| Kcns3 | 0.043 | 1.911 | Csnk1g1 | 0.029 | 1.465 | Htr3b | 0.026 | 1.329 |
| Irs1 | 0.023 | 1.636 | Kcnc3 | 0.016 | 1.377 | Htr4 | 0.022 | 2.801 |
| Cacng5 | 0.007 | 1.420 | Kcna4 | 0.024 | 1.588 | Prkch | 0.018 | 1.526 |
| Cacna2d3 | 0.016 | 1.755 | Ache | 0.038 | 1.355 | |||
| DOWN (931) | Kcnip2 | 0.028 | 1.628 | Ppp1r1a | 0.029 | 1.375 | ||
| Htr4 | 0.038 | 2.030 | Grm5 | 0.006 | 1.393 | Drd1a | 0.049 | 1.467 |
| Th | 0.016 | 1.436 | Grm4 | 0.008 | 1.440 | PDE 1B | 0.009 | 1.411 |
| Adora2a | 0.048 | 1.852 | Cdk6 | 0.011 | 1.852 | Adora2a | 0.034 | 1.387 |
| Prkch | 0.044 | 1.740 | Rgs2 | 0.007 | 1.544 | Kcnh4 | 0.039 | 1.350 |
| Drd1a | 0.032 | 1.852 | Rgs3 | 0.027 | 1.775 | Ppp1r2 | 0.013 | 1.390 |
| Ppp1r1b | 0.042 | 1.960 | Rgs8 | 0.037 | 1.634 | GPR149 | 0.020 | 1.684 |
| Pde10a | 0.041 | 1.705 | Rgs9 | 0.044 | 1.879 | Nts | 0.021 | 1.763 |
| Pde1c | 0.011 | 1.673 | Rgs10 | 0.028 | 1.476 | |||
| Camk4 | 0.045 | 1.559 | Gpr6 | 0.032 | 1.764 | DOWN (253) | ||
| Pde4b | 0.045 | 1.550 | Gpr88 | 0.039 | 1.889 | Adra2a | 0.045 | 1.773 |
| Adcy5 | 0.023 | 1.879 | Gpr149 | 0.041 | 1.961 | Gria3 | 0.032 | 1.671 |
| Cart | 0.044 | 1.825 | Gad1 | 0.041 | 1.702 | Kcnmb4 | 0.014 | 1.539 |
| Junb | 0.029 | 1.801 | Dgkb | 0.049 | 1.557 | Homer1 | 0.040 | 1.494 |
| Kcnj4 | 0.024 | 1.588 | Gpr51 | 0.046 | 1.536 | |||
| Calb1 | 0.037 | 1.512 | ||||||
CON, control; IMI, imipramine; SI, social isolation.