Table 2.

NRTI Mutation 184V Increases Phenotypic Susceptibility to d4T, ZDV, and TDF and Decreases Phenotypic Susceptibility to ABC, 3TC, and DD1

	Phenotype (FC IC50)
	NRTI						NNRTI
Genotype	ABC	ddl	3TC	d4T	TDF	ZDV	DLV	EFV	NVP	RC%
Pt 19
101E, 190S	2.6	1.7	3.0	2.1	1.0	3.7	0.3	240	> >a	100
41L, 74V, 215Y
101E, 190S	5.8	2.6	> >	1.4	0.4	1.0	0.2	95	220	41
41L, 74V, 184V, 215Y
101E, 190S	3.3	2.0	2.5	2.9	1.2	12	0.3	282	> >	117
41L, 74V, 210W, 215Y
101E, 190S	7.8	3.1	> >	1.6	0.5	1.1	0.1	92	161	29
41L, 74V, 184V, 210W, 215Y
NNRTI revertedb	2.0	1.5	2.7	1.9	0.6	1.8	0.1	0.2	0.2	39
41L, 74V, 210W, 215Y
NNRTI reverted	6.3	2.5	> >	1.7	0.3	0.7	0.1	0.1	0.1	18
41L, 74V, 184V, 210W, 215Y
NNRTI reverted	1.7	1.1	2.2	1.8	1.1	6.8	0.1	0.3	0.2	62
41L, 210W, 215Y
NNRTI reverted	3.8	1.2	> >	1.0	0.5	0.9	0.01	0.2	0.2	30
41L, 184V, 210W, 215Y
Pt 8
41L, 210W, 215Y	2.7	1.3	2.1	2.3	3.3	197	0.5	0.4	0.7	51
41L, 184V, 210W, 215Y	5.4	1.5	> >	1.6	1.2	13	0.3	0.3	0.5	48

^aIndicates maximal limit of FC detected by phenotype assay, PhenoSense.

^bIndicates NNRTI resistance mutations K101E and G190S have been modified to confer wild-type amino acids at these positions.