Table 4.

NNRTI Mutations 101E and 190S Tend to Decrease Susceptibility to NRTI, as Well as NNRTI, but NNRTI Mutation 103N Has Modest Effect on NRTI Susceptibility While Markedly Decreasting NNRTI Susceptibility

	Phenotype (FC IC50)
	NRTI						NNRTI
Genotype	ABC	ddl	3TC	d4T	TDF	ZDV	DLV	EFV	NVP	RC%
Pt 19
101E, 190S	2.6	1.7	3.0	2.1	1.0	3.7	0.3	240	> >a	100
41L, 74V, 215Y
NNRTI revertedb	1.9	2.0	2.1	1.4	0.6	1.1	0.1	0.1	0.1	28
41L, 74V, 215Y, 215Y
101E, 190S	2.6	1.6	2.6	2.1	0.9	3.1	0.6	248	> >	104
41L, 74V, 215Y, 219Q
NNRTI reverted	1.5	1.3	1.4	1.0	0.4	0.3	0.3	0.3	0.2	69
41L, 74V, 219Q
101E, 190S	1.5	1.7	2.2	1.0	0.7	0.6	0.8	> >	> >	77
41L, 67N, 74V, 215Y, 219Q
NNRTI reverted	1.1	1.4	1.2	0.9	0.4	0.4	0.2	0.2	0.2	50
41L, 67N, 74V, 215Y, 219Q
101E, 190S	7.8	3.1	> >	1.6	0.5	1.1	0.1	92	161	29
41L, 74V, 184V, 210W, 215Y
NNRTI reverted	6.3	2.5	> >	1.7	0.3	0.7	0.1	0.1	0.1	18
41L, 74V, 184V, 210W, 215Y
Pt 8
41L, 210W, 215Y	2.7	1.3	2.1	2.3	3.3	197	0.5	0.4	0.7	51
103N
41L, 210W, 215Y	2.2	1.6	2.4	2.4	2.8	546	17	16	36	80
41L, 184V, 210W, 215Y	5.4	1.5	> >a	1.6	1.2	13	0.3	0.3	0.5	48
103N
41L, 184V, 210W, 215Y	4.2	1.8	> >	2.0	1.0	43	12	13	27	60
41L, 67N, 210W, 215Y	2.6	1.6	4.6	2.8	2.7	> >	21	0.3	0.4	93
103N
41L, 67N, 210W, 215Y	3.5	1.4	4.4	2.6	4.0	> >	16	16	39	46
41L, 67D, 210W, 215Y	3.4	1.7	4.3	2.5	2.6	75	0.4	0.4	0.6	92
103N
41L, 67D, 210W, 215Y	3.3	1.6	4.8	2.4	2.8	167	21	18	44	92
41L, 210W, 215Y, 219Q	1.4	1.4	2.2	1.9	1.7	58	1.2	0.8	0.8	61
103N
41L, 210W, 215Y, 219Q	2.2	1.1	1.7	1.8	2.6	101	58	14	28	46

^aIndicates over the maximal limit of FC detected by phenotype assay, PhenoSense.

^bIndicates NNRTI resistance mutations K101E and G190S have been modified to confer wild-type amino acids at these positions.