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. Author manuscript; available in PMC: 2009 Aug 5.
Published in final edited form as: Nature. 2009 Feb 5;457(7230):694–698. doi: 10.1038/nature07724

Figure 3.

Figure 3

The 30-nm RSV-CA double-layer capsid. a, Surface rendering of cryo-EM reconstruction showing the outer T=3 capsid (yellow) and the inner T=1 capsid (green), exposed in b by removal of the front half of the outer layer. Bar, 10 nm. Neighboring hexamers are 10.2 nm apart, center-to-center, at mid-floor, while the spacing between hexamers and pentamers is 9.5 nm. c, Pseudo-atomic model of the T=3 capsid. An asymmetric unit contains three CA subunits: P1 in pentamers (red); and H1 (blue) and H2 (green) in hexamers. In the T=3 shell, pentamers and hexamers interact via the CTD-CTD interface between P1 and H1, while adjacent hexamers interact via H2. d, Interactions between the two layers. NTDs of the T=1 capsid (orange) contact CTDs of H1 subunits in the T=3 capsid (blue). Highlighted in yellow is the loop between helices 4 and 5 in the NTD, and in cyan, the major homology region in the CTD.