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. 2009 Aug 5;106(33):14052–14057. doi: 10.1073/pnas.0906735106

Fig. 4.

Fig. 4.

Salmonella-induced class II down-regulation requires residues in the cytoplasmic tail of the DRβ chain. (A) Amino acid sequence of the carboxyl terminal region of the HA-DRα and HA-DRβ constructs used to generate stable Mel JuSo transfectants. Substituted residues are shown in bold. (B) Left panels show representative FACS histogram profiles of surface HA expression in infected and uninfected HA-DRβ transfectants and the percentage down-regulation is shown on the far right. Dots show results from independent experiments. P values, P = 0.024, P < 0.001. (C) FACS profiles show surface HA expression of tagged DRα constructs in infected and uninfected Mel JuSo cells. Histograms show levels of surface HA-DR expression in infected (hatched) and uninfected (open) Mel JuSo cells.