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The captured gene pairs in the protein-protein interaction database
| Rank | Number of times | Gene pair | ||
| 1 | 70 | AKT1 | - | CHUK |
| 2 | 38 | ACVRL1 | - | TGFB1 |
| 3 | 24 | AGRP | - | MC3R |
| 4 | 21 | BAK1 | - | BAX |
| 5 | 17 | CASP10 | - | FADD |
| 6 | 15 | BAX | - | BCL2L1 |
| 6 | 15 | BMPR1A | - | BMPR1B |
| 8 | 14 | ACVRL1 | - | TGFBR2 |
| 8 | 14 | CASP10 | - | CFLAR |
| 8 | 14 | CASP8 | - | FADD |
| 11 | 13 | APC | - | AXIN2 |
| 12 | 12 | BAK1 | - | BCL2L1 |
| 13 | 11 | A2M | - | APOE |
| 13 | 11 | ABL1 | - | BCR |
| 13 | 11 | APAF1 | - | CASP9 |
| 13 | 11 | ARNTL | - | CLOCK |
| 13 | 11 | CASP8 | - | CASP10 |
