Fig. 3. Lung MMP Expression in response to P. aeruginosa Pneumonia.
Whole lung RNA was collected at serial times after exposure to P. aeruginosa and levels of specific transcripts were determined by qRT-PCR and normalized to HPRT. Reported are fold change in mRNA levels relative to time 0. (A) MMP-28 expression was rapidly downregulated and returned to baseline after resolution of infection and inflammation. (B-E) In contrast to MMP-28, other MMPs, (MMP-7,−10,−12, and −14) were induced during infection (*p<0.05 compared with timepoint 0). n=4−5 mice/timepoint.
