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. 2009 Aug 28;5(8):e1000487. doi: 10.1371/journal.pcbi.1000487

Figure 8. The protein stability analysis of the ABL and EGFR cancer mutants.

Figure 8

Left Panel (A): The computed protein stability changes between ABL-WT and ABL-T315I, ABL-L387M mutants in the Src-like inactive and active states of ABL. Right Panel (B): The computed protein stability changes upon EGFR-T790M, EGFR-L858R mutants in the Src/Cdk-like inactive and active states of EGFR. In both panels, a negative value in the protein stability difference between the WT kinase and a respective mutant corresponds to a destabilization effect of the mutant.