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. 2009 Aug 28;5(8):e1000487. doi: 10.1371/journal.pcbi.1000487

Figure 14. A mechanistic analysis of the TMD activation pathways for the ABL-L387M and EGFR-L858R mutations.

Figure 14

A dynamic assembly of the hydrophobic spine during TMD simulations is shown for the ABL-L387M mutant (upper panel) and the EGFR-L858R mutant (lower panel). (A) The initial model of ABL-L387M in the inactive form. (B) The characteristic TMD intermediate of ABL-L387M. (C) The final structure of ABL-L387M in the active form. (D) The initial model of EGFR-L858R in the inactive form. (B) The characteristic TMD intermediate of EGFR-L858R. (C) The final structure of EGFR-L858R in the active form. The assembled hydrophobic spine is present in all TMD intermediates.