Figure 5.
The requirement and optimal concentration of serum was tested in the culture. Serum was shown to be a necessary factor driving glial scar formation (p<.05 no serum condition vs. any condition with serum) but even very low amounts of serum could induce some scar formation. While there was a qualitative correlation between higher serum and greater scarring, there was no significant difference between conditions as long as some serum was present. Black bar indicates “Base Protocol” conditions.