Table 1.

Description of 25 sporadic unilateral RB tumors

ID	Sex	Age at enucleation	LOH of Chromosome 13	Coding Sequence Mutation at RB1 locus	Change (amino acid)/Splicing	Number of Aberrations
014	female	2.0	No	g. 2162C>T, exon 1	p.Q35X	7
020	female	2.1	No	ND*		1
042	female	0.5	No	g. 78238C > T, exon 17	p.R552X	15
044	male	1.1	Yes	ND		25
142	female	2.4	Yes	g. 61797G>A, exon 9	p.G310E	10
223	male	5.5	Yes	ND		3
233	female	3.2	Yes	DEL EXON 15,16 and 20		25
443	male	2.6	Yes	ND		25
490	female	0.2	Yes	ND		1
503	female	1.9	No	g. 76898C>T, exon 15, g. 156833G> A, exon 20	p.R467X, p.W681X	2
501	female	2.4	Yes	g. 76460C> T, exon 14	p.R455X	2
510	male	2.5	Yes	ND		1
520	female	0.9	Yes	ND		5
530	female	0.9	Yes	ND		3
610	male	3.2	Yes	ND		25
620	male	1.0	No	g. 335InsTA, exon 2; g. 2364InsTTGA, exon 22	p.76X, p.750X	1
630	female	4.5	Yes	g. 16184T>A, at −13 position of intron 21	Novel splice acceptor	25
710	male	7.4	Yes	g. 150037C>T, exon 18	p.R579X	16
791	female	1.7	Yes	g. 73750A>G, at −3 position of intron 12.	Novel splice acceptor	4
840	female	0.7	Yes	g. 65386C>T, exon 11	p.R358X,	25
860	female	2.5	Yes	g. 150117 G>A, at +1 position of intron 18	Splice donor	1
902	female	2.5	Yes	g. 160740 G>A, exon 21	p.C706Y	25
912	female	0.3	Yes	ND		0
913	male	0.4	No	ND		0
920	male	0.9	Yes	g. 153198 A> G, at −12 position of intron 18	Novel splice acceptor	5

^*ND – Not detected