The fan mutant displays reduced behavioral sensitivity to ethanol. A, The fan mutant shows normal basal locomotor activity. B, The fan mutant is less sensitive to ethanol-evoked hyperlocomotor activity (right). *p < 0.05, **p < 0.01, ***p < 0.001, n = 28 and 35 for fan/fan and +/+, respectively. C, Locomotor activity of WT sibling and the fan mutant after treatment with 3% ethanol in the medium. Ethanol-induced hypo-locomotion is not significantly different between WT sibling and the fan mutant (n = 11 for each genotype). D, Locomotor activity of WT sibling and the fan mutant recovering from 18 min treatment with 3% ethanol in the medium. The fan mutant recovers significantly faster than WT sibling (*p < 0.05, n = 37 and 36 for fan/fan and +/+, respectively).