Table IV.
Tumor multiplicity in the small and large intestine of C57/Bl6 mice at three time points during 24 months of feeding
| N | Number of tumors per mouse |
|||
| Overall | Small intestine | Large intestine (colon) | ||
| 12 months | ||||
| AIN-76A | 12 | 0.00 ± 0.00 (0–0) | 0.00 ± 0.00 (0–0) | 0.00 ± 0.00 (0–0)A |
| NWD | 13 | 0.00 ± 0.00 (0–0) | 0.00 ± 0.00 (0–0) | 0.00 ± 0.00 (0–0) |
| NWD/CaD | 13 | 0.15 ± 0.10 (0–1) | 0.15 ± 0.10 (0–1) | 0.00 ± 0.00 (0–0) |
| NWD/FA | 14 | 0.07 ± 0.07 (0–1) | 0.07 ± 0.07 (0–1) | 0.00 ± 0.00 (0–0) |
| NWD/Chln | 10 | 0.20 ± 0.13 (0–1) | 0.10 ± 0.10 (0–1) | 0.10 ± 0.10 (0–1) |
| NWD/Methn | 18 | 0.39 ± 0.20 (0–3)a | 0.17 ± 0.09 (0–1)b | 0.22 ± 0.13 (0–2)c |
| NWD/Fb | 16 | 0.06 ± 0.06 (0–1) | 0.06 ± 0.06 (0–1) | 0.00 ± 0.00 (0–0) |
| 18 months | ||||
| AIN-76A | 18 | 0.28 ± 0.14 (0–2) | 0.22 ± 0.10 (0–1) | 0.06 ± 0.06 (0–1) |
| NWD | 22 | 0.32 ± 0.23 (0–5) | 0.09 ± 0.06 (0–1) | 0.23 ± 0.23 (0–5) |
| NWD/CaD | 22 | 0.14 ± 0.08 (0–1) | 0.09 ± 0.06 (0–1) | 0.05 ± 0.05 (0–1) |
| NWD/FA | 23 | 0.30 ± 0.10 (0–1) | 0.26 ± 0.09 (0–1) | 0.04 ± 0.04 (0–1) |
| NWD/Chln | 23 | 0.22 ± 0.13 (0–2) | 0.13 ± 0.07 (0–1) | 0.09 ± 0.06 (0–1) |
| NWD/Methn | 18 | 0.22 ± 0.10 (0–1) | 0.11 ± 0.08 (0–1) | 0.11 ± 0.11 (0–1) |
| NWD/Fb | 17 | 0.06 ± 0.06 (0–1) | 0.00 ± 0.00 (0–0) | 0.06 ± 0.06 (0–1) |
| 24 months | ||||
| AIN-76A | 15 | 0.27 ± 0.15 (0–2)B | 0.20 ± 0.11 (0–1) | 0.07 ± 0.15 (0–1)C |
| NWD | 15 | 0.67 ± 0.19 (0–2)1 | 0.33 ± 0.13 (0–1) | 0.33 ± 0.16 (0–2) |
| NWD/CaD | 18 | 0.06 ± 0.06 (0–1)a | 0.06 ± 0.06 (0–1)c | 0.00 ± 0.00 (0–0)c |
| NWD/FA | 18 | 0.56 ± 0.17 (0–2) | 0.22 ± 0.10 (0–1) | 0.22 ± 0.10 (0–2) |
| NWD/Chln | 18 | 0.44 ± 0.19 (0–3) | 0.39 ± 0.14 (0–2) | 0.06 ± 0.06 (0–1)d |
| NWD/Methn | 16 | 0.63 ± 0.27 (0–4) | 0.44 ± 0.26 (0–4) | 0.19 ± 0.10 (0–1) |
| NWD/Fb | 17 | 0.59 ± 0.30 (0–5) | 0.18 ± 0.13 (0–2) | 0.41 ± 0.19 (0–3) |
N, number of mice studied. Mean ± SEM (range). By Kruskal–Wallis test multiple comparison among seven groups: AP = 0.096; BP = 0.084; CP = 0.078. By Mann–Whitney test or binomial calculation, compared with AIN-76A, 1P = 0.079; compared with NWD, aP < 0.01; bP = 0.073; cP < 0.02; dP < 0.098. The numbers in parentheses indicate the range of tumor numbers per mouse in each group.