Table III.
Tumors | Exon | Nucleotide position | Codon | Nucleotide | Predicted amino acid |
KO4a | 5 | +8114 | 159 | atc → gtc | Iso → Thr |
KO4b | 5 | +8114 | 159 | atc → gtc | Iso → Thr |
KO5 | 5 | +8115 | 159 | atc → acc | Iso → Val |
No mutations were identified in 5/5 tumors from WT mice, whereas three p53 mutations were detected in two of five tumors assayed from Hsp70 KO mice.