Table III.

NER SNPs and CRC risk

Gene	CRC					Colon cancer				Rectal cancer				Site diff P-valueb
	Minor allele frequency	Co/Ca	ORa	95% CI	P-value	Co/Ca	ORa	95% CI	P-value	Co/Ca	ORa	95% CI	P-value
MLH1/Ile219Val
Ile/Ile	0.29	194/161	1.0Ref			80/69	1.0Ref			111/92	1.0Ref
Ile/Val + Val/Val		160/140	1.1	0.7–1.6	0.678	67/59	1.0	0.6–1.9	0.915	93/81	1.1	0.7–1.9	0.65	0.83
MSH2 Gly322Asp
Gly/Gly	0.02	348/291	1.0Ref			144/124	1.0Ref			201/167	1.0Ref
Gly/Asp + Asp/Asp		13/16	3.6	0.7–18	0.113	5/6	2.0	0.2–22	0.571	8/10	5.3	0.6–46	0.134	0.559
ERCC1 3′ UTR
G/G	0.27	206/162	1.0Ref			82/69	1.0Ref			124/93	1.0Ref
G/T + T/T		153/142	1.3	0.8–1.9	0.255	66/59	1.2	0.6–2.2	0.622	84/83	1.4	0.8–2.4	0.275	0.704
XPD Asp312Asn
Asp/Asp	0.33	161/142	1.0Ref			73/65	1.0Ref			87/77	1.0Ref
Asp/Asn + Asn/Asn		200/165	1.0	0.6–1.4	0.813	76/65	1.0	0.5–1.9	0.911	122/100	0.9	0.6–1.6	0.831	0.962
XPD Lys751Gln
Lys/Lys	0.34	153/124	1.0Ref			62/56	1.0Ref			90/68	1.0Ref
Lys/Gln + Gln/Gln		209/184	1.2	0.8–1.8	0.447	88/74	0.9	0.5–1.8	0.778	119/110	1.4	0.8–2.4	0.229	0.325
XPC intron 11
C/C	0.39	139/117	1.0Ref			64/52	1.0Ref			74/65	1.0Ref
C/A + A/A		222/191	1.0	0.7–1.5	0.862	85/78	1.1	0.6–2.1	0.748	135/113	1.0	0.6–1.7	0.968	0.784
XPA 5′ UTR
C/C	0.33	149/136	1.0Ref			52/61	1.0Ref			94/75	1.0Ref
C/T + T/T		200/166	0.8	0.5–1.2	0.211	91/66	0.4	0.2–0.8	0.011	109/100	1.1	0.7–2.0	0.641	0.016
XPF Arg415Gln
Arg/Arg	0.10	313/265	1.0Ref			129/112	1.0Ref			181/153	1.0Ref
Arg/Gln + Gln/Gln		47/40	1.0	0.5–1.9	0.978	19/17	0.9	0.3–2.7	0.851	28/23	1.0	0.5–2.3	0.919	0.832
XPG Asp1104His
Asp/Asp	0.22	213/183	1.0Ref			85/75	1.0Ref			126/108	1.0Ref
Asp/His + His/His		148/125	1.0	0.7–1.6	0.950	65/55	0.9	0.5–1.9	0.835	82/70	1.1	0.6–1.9	0.807	0.753

^aUnadjusted.

^bP-value from colon versus rectum heterogeneity test.