Figure 3.
Assessment of in vivo cardiac morphology and function. (A) M-mode and two-dimensional echocardiography in WT, Tg-WT, and Tg-NS/H mice displaying LV and RV chamber dilatation in mutant mice. (B) Mean values of echocardiographic parameters from WT, Tg-WT, and Tg-NS/H mice, including LV and RV end-diastolic diameter (LVEDD and RVEDD, respectively), LV and RV end-systolic diameter (LVESD and RVESD, respectively), RV area (RV area in diastole [short-axis view]), and LV fractional shortening (LVFS). Data represent means ± SEM from single independent echocardiographic measurements on five mice per experimental group (#, P < 0.05 vs. WT; *, P < 0.001 vs. WT; $, P < 0.01 vs. Tg-WT; &, P < 0.001 vs. Tg-WT; Table S3).