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. 2009 Aug 3;206(8):1787–1802. doi: 10.1084/jem.20090641

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© 2009 Pilichou et al.

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Figure 5. — Gross features of explanted mouse hearts. (A) Tg-NS/H, Tg-WT, and WT hearts at age <2 (a, d, and g), 5 (b, e, and h), 10 (c, f, and i) wk. Note the structurally normal hearts at young age, with later appearance of calcification and dilatation with aneurysms (arrows) in Tg-NS/H hearts. Bars: (a, b, and d–i) 1 mm; (c) 2 mm. (B) Mean values of HW/BW ratios; LV, RV, and ventricular septum (VS) wall thicknesses; and cardiomyocyte diameters in hearts of different age groups (<3, 3–6, and 6–12 wk; 10 mice per age group for each line; #, P < 0.01 vs. WT; ‡, P < 0.01 vs. Tg-WT; Table S5).