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. 2009 Aug 3;206(8):1739–1753. doi: 10.1084/jem.20090004

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© 2009 Trageser et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Progressive leukemic transformation of B cell precursors in BCR-ABL1 transgenic mice. B cell precursors from wild-type and BCR-ABL1 transgenic mice were analyzed for their clonality using spectratyping of Ig gene rearrangements (A), μ chain expression (B), pre–B cell receptor responsiveness (C), and gene expression pattern (D), and RT-PCR validation (E; three experiments). Data in A–C are representative of results from six independent experiments with at least two mice per group. B cell precursor populations were compared from wild-type animals, preleukemic BCR-ABL1 transgenic mice (age <60 d), BCR-ABL1 transgenic mice with full-blown leukemia (age >90 d), and after treatment of mice with AMN107 (75 mg/kg/d) for 7 d.