Table 2.

ADH and ALDH2 gene marker information

Gene	Chr	SNP	Chromosome locationa	Gene locationb	Alleles Minorc	Major	MAF	pHWEd	Call rate (%)
METAP1	4	rs1230210	100 186 714	Intron 5	T	C	0.273	0.39	99.2
ADH5	4	rs1230165	100 205 396	3′-UTR	C	T	0.181	0.79	99.1
ADH5	4	rs896992	100 221 395	Intron 4	G	A	0.329	1.00	99.1
ADH5	4	rs1154409	100 226 893	Intron 1	T	G	0e	1.00	99.3
	4	rs2602877	100 258 870	Intergenic	A	T	0.271	0.59	99.1
	4	rs2602878	100 258 976	Intergenic	A	C	0.270	0.57	99.1
ADH4	4	rs1042364	100 264 597	3′-UTR	A	G	0.277	1.00	99.1
ADH4	4	rs1126672	100 266 835	Exon 8	T	C	0.278	0.65	99.4
ADH4	4	rs1800759	100 284 532	Promoter	A	C	0.385	0.18	98.6
ADH4	4	rs4140388	100 284 757	Upstream	C	G	0.459	0.69	98.4
	4	rs3762894	100 285 107	Intergenic	G	A	0.160	0.98	98.7
	4	rs1984364	100 289 806	Intergenic	G	T	0.275	0.95	99.2
	4	rs1540053	100 301 177	Intergenic	C	T	0.235	0.95	98.6
ADH6	4	rs2000864	100 342 799	Downstream	T	G	0.487	0.43	98.9
ADH6	4	rs4147545	100 347 776	Intron 6	G	A	0.320	0.24	99.4
	4	rs1230025	100 405 399	Intergenic	T	A	0.230	0.51	98.0
ADH1A	4	rs3819197	100 419 532	Intron 8	A	G	0.231	0.05	98.6
ADH1A	4	rs2276332	100 422 470	Intron 6	G	T	0.086	0.68	98.9
ADH1B	4	rs1042026	100 447 489	3′-UTR	G	A	0.279	0.92	98.6
ADH1B	4	rs17033	100 447 968	3′-UTR	G	A	0.086	0.52	99.5
ADH1B	4	rs6850217	100 452 643	Intron 6	A	G	0.390	0.72	99.2
ADH1B	4	rs2018417	100 454 163	Exon 6	T	G	0.040	1.00	98.9
ADH1B	4	rs4147536	100 458 135	Intron 3	T	G	0.213	0.89	99.0
ADH1B	4	rs1229984	100 458 342	Exon 3	A	G	0.035	0.11	99.0
ADH1B	4	rs1159918	100 462 032	Upstream	T	G	0.361	0.89	98.9
	4	rs2866152	100 470 090	Intergenic	G	C	0.244	0.98	99.5
ADH1C	4	rs1789895	100 475 752	Downstream	C	G	0.323	0.60	98.9
ADH1C	4	rs3098808	100 475 847	Downstream	C	T	0.114	<0.0001	97.7
ADH1C	4	rs1693482	100 482 988	Exon 6	A	G	0.410	0.84	98.7
ADH1C	4	rs283416	100 490 379	Intron 1	T	C	0.065	1.00	98.6
	4	rs1583973	100 506 906	Intergenic	T	C	0.099	0.95	98.8
	4	rs1826906	100 520 071	Intergenic	C	T	0.326	0.45	99.1
	4	rs2032350	100 533 085	Intergenic	T	C	0.198	0.08	98.5
	4	rs1348276	100 544 653	Intergenic	G	T	0.410	0.48	98.5
	4	rs994772	100 546 687	Intergenic	A	G	0.106	0.87	98.8
ADH7	4	rs284784	100 554 897	Intron 8	T	G	0.270	<0.0001	98.4
ADH7	4	rs1154454	100 557 365	Intron 7	C	T	0.163	1.00	99.3
ADH7	4	rs1154458	100 559 545	Intron 6	G	C	0.408	0.23	98.8
ADH7	4	rs971074	100 560 884	Exon 6	A	G	0.113	0.97	99.4
ADH7	4	rs1154461	100 561 925	Intron 5	C	G	0.351	0.45	98.8
	4	rs1583971	100 626 045	Intergenic	A	T	0.111	0.08	99.7
ALDH2	12	rs737280	110 657 696	Upstream	C	T	0.272	0.04	97.3
ALDH2	12	rs886205	110 667 147	5′-UTR	G	A	0.170	0.20	99.0
ALDH2	12	rs2238151	110 674 553	Intron 1	C	T	0.322	0.07	99.0
ALDH2	12	rs4648328	110 685 508	Intron 3	T	C	0.165	0.10	99.1
ALDH2	12	rs441	110 691 569	Intron 6	C	C	0.184	0.68	97.9
ALDH2	12	rs968529	110 697 088	Intron 9	T	C	0.069	0.19	95.4
ALDH2	12	rs4646778	110 698 503	Intron 9	A	C	0.165	0.17	99.1
ALDH2	12	rs671	110 704 486	Exon 12	A	G	0e	1.00	99.3
ALDH2	12	rs16941667	110 707 133	Intron 12	T	C	0.079	0.23	99.4

Chr, chromosome; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; SNP, single-nucleotide polymorphism; UTR, untranslated region.

^aPosition in nucleotides as estimated in dbSNP (Build 127).

^bPosition within or near gene.

^cThe allele with the lowest frequency.

^dpHWE = P-value for the Hardy–Weinberg equilibrium test run in PEDSTATS (71).

^ers671 and rs1154409 are non-polymorphic.