Table 1.
Changes in the body weight (g); testis absolute (mg) and relative weights (%) and some sexual hormones in male albino rats treated with aflatoxinB1 and phytic acid
| Treatment period | Recovery period | |||||
|---|---|---|---|---|---|---|
| 3 days | 7 days | 14 days | 21 days | 28 days | ||
| Body weight (g) | Control | 106 ± 9.617 | 82 ± 13.038 | 118 ± 15.652 | 119 ± 8.341 | 130 ± 3.780 |
| AFB1 | 83 ± 11.511 | 99 ± 15.166 | 109 ± 16.335 | 112 ± 11.381 | 137 ± 16.808 | |
| Phytic acid | 88 ± 20.186 | 105 ± 16.583 | 115 ± 18.027 | 115 ± 10.481 | 123 ± 13.038 | |
| AFB1+Phytic | 82 ± 12.549 | 92 ± 16.047 | 104 ± 11.937 | 110 ± 9.350 | 142 ± 16.807 | |
| Testis wt (mg) | Control | 508.4 ± 21.733 a | 451.22 ± 79.550 a | 508.00 ± 43.871 a | 520.96 ± 30.654 a | 599.80 ± 84.715 a |
| AFB1 | 272.44 ± 43.384 c | 358.80 ± 55.693 b | 361.40 ± 57.317 c | 370.45 ± 45.783 b | 479.80 ± 15.465 b | |
| Phytic acid | 388.68 ± 84.767 b | 395.00 ± 21.161 b | 488.80 ± 70.574ab | 455.63 ± 40.841 ab | 507.00 ± 37.195 b | |
| AFB1+Phytic | 299.88 ± 24.033 c | 459.00 ± 35.979 a | 400.20 ± 97.568 bc | 387.12 ± 80.439 b | 474.40 ± 68.449 b | |
| Relative wt (% × 10−3) | Control | 4.822 ± 0.403 a | 4.116 ± 0.388 ab | 4.358 ± 0.533 | 4.650 ± 0.343 | 4.598 ± 0.402 a |
| AFB1 | 3.305 ± 0.439 b | 3.612 ± 0.277 b | 4.038 ± 0.508 | 3.967 ± 0.245 | 3.508 ± 0.257 b | |
| Phytic acid | 4.433 ± 0.469 a | 3.622 ± 0.370 b | 4.526 ± 1.119 | 4.232 ± 0.567 | 4.154 ± 0.449 a | |
| AFB1+Phytic | 3.702 ± 0.378 b | 4.000 ± 0.823 a | 3.991 ± 1.213 | 3.989 ± 0.287 | 4.194 ± 0.826 a | |
| Testosterone (ng ml−1) | Control | 0.876 ± 0.030 a | 0.950 ± 0.137 a | 0.900 ± 0.107 a | 0.920 ± 0.036 a | 0.93 ± 0.239 a |
| AFB1 | 0.476 ± 0.045 b | 0.506 ± 0.165 b | 0.513 ± 0.058 c | 0.550 ± 0.064 c | 0.51 ± 0.126 b | |
| Phytic acid | 0.806 ± 0.059 a | 0.820 ± 0.126 a | 0.846 ± 0.045 a | 0.780 ± 0.062 b | 0.77 ± 0.165 ab | |
| AFB1+Phytic | 0.866 ± 0.065 a | 0.856 ± 0.102 a | 0.670 ± 0.036 b | 0.850 ± 0.055 ab | 0.80 ± 0.118 a | |
| FSH (ng ml−1) | Control | 0.579 ± 0.048 a | 0.636 ± 0.010 a | 0.610 ± 0.0476 a | 0.600 ± 0.0135 a | 0.615 ± 0.0534 ab |
| AFB1 | 0.403 ± 0.018 c | 0.429 ± 0.0537 c | 0.400 ± 0.0367 b | 0.421 ± 0.022 b | 0.458 ± 0.0525 b | |
| Phytic acid | 0.623 ± 0.016 a | 0.599 ± 0.061 a | 0.618 ± 0.0313 a | 0.615 ± 0.018 a | 0.761 ± 0.146 a | |
| AFB1+Phytic | 0.476 ± 0.049 b | 0.509 ± 0.011 b | 0.428 ± 0.0393 b | 0.580 ± 0.020 a | 0.606 ± 0.628 ab | |
| LH (ng ml−1) | Control | 2.499 ± 0.397 a | 2.243 ± 0.278 ab | 2.369 ± 0.235 | 2.339 ± 0.0533 a | 2.384 ± 0.339 a |
| AFB1 | 0.996 ± 0.079 c | 1.493 ± 0.373 c | 1.587 ± 0.244 | 1.510 ± 0.022 c | 1.677 ± 0.315 b | |
| Phytic acid | 1.818 ± 0.065 b | 2.593 ± 0.173 a | 2.379 ± 0.593 | 2.170 ± 0.160 a | 1.797 ± 0.279 b | |
| AFB1+Phytic | 1.475 ± 0.508 bc | 1.944 ± 0.473 bc | 1.823 ± 0.509 | 1.816 ± 0.023 b | 1.289 ± 0.284 b | |
Number of animals = 6; Values are expressed as Means ± SD; AFB1, aflatoxinB1; Means within same parameter with the same letter are not significantly different (P > 0.05).