Table 1.

Genotype Distributions of ESR1 tag SNPs after Stage 2 (SEARCH Sets 1 and 2)

Haplotype block	rs number	Minor allele frequency	Genotype	Controls	Cases	Odds ratio (95% CI)	Trend test P-value
2	rs2234693 PvuII	0.46	TT	1318	1260	1a	0.48
			TC	2296	2164	0.99 [0.89–1.09]
			CC	934	938	1.05 [0.93–1.18]
2	rs9340799 XbaI	0.35	AA	1873	1682	1a	0.09
			AG	2048	1967	1.07 [0.98–1.17]
			GG	526	521	1.10 [0.96–1.27]
3	rs1709182	0.36	TT	1796	1669	1a	0.08
			TC	2117	2017	1.03 [0.94–1.12]
			CC	607	642	1.14 [1.00–1.30]
4b	rs3020314	0.31	TT	2132	1869	1a	0.00008
			TC	1970	1989	1.15 [1.05–1.26]
			CC	447	499	1.27 [1.10–1.46]
4b	rs3020317	0.19	TT	2983	2746	1a	0.003
			TC	1420	1427	1.09 [1.00–1.19]
			CC	151	188	1.35 [1.08–1.69]
4c	rs926777	0.24	CC	2566	2401	1a	0.16
			CA	1722	1703	1.06 [0.97–1.15]
			AA	266	271	1.09 [0.91–1.30]

Values in the minor allele frequency column refer only to Controls. Values in bold denote statistically significant results.

^aReferent group.