Figure 2.

CenH3 is a highly divergent histone H3 variant that evolves very rapidly. Sequence comparison of the N-terminal domain (A) and the histone-fold domain (HFD) (B) of CenH3 proteins from different species, ranging from S. cerevisiae to humans, is shown. The sequence of canonical histone H3 is shown at the bottom for comparison. R-rich motives are indicated in A. Secondary structure of the HFD is indicated in B. The position of the CATD, which mediates centromeric targeting of CenH3 and confers distinct structural properties to CenH3-nucleosomes, is indicated.