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. 2009 Jul 23;28(16):2337–2348. doi: 10.1038/emboj.2009.174

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Copyright © 2009, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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Kinetochores are large macromolecular entities. (A) Various protein complexes/networks are known to act at different stages of kinetochore assembly. These include the KNM network (KNL1, NDC80 and MIND), which is involved in microtubule binding, and the NAC/CAD network that directly associates to centromeric chromatin. (B) CenH3 is essential for kinetochore assembly. CenH3 is at the bottom of a complex network of interactions that, ultimately, leads to assembly of a fully functional kinetochore. Dependencies for centromeric/kinetochore localisation are indicated by solid arrows. Possible interactions, observed only in some species or not fully confirmed, are indicated by dotted arrows.