Figure 2:

Genetic background alters startle responsiveness in zebrafish larvae. AB strain (n = 108) and Tubingen strain (n = 99) larvae were raised in identical conditions and subjected to the startle and prepulse inhibition conditions used for screening [31]. The two strains differed significantly in the mode of startle response used. AB strain larvae predominantly used ‘SLC’ (Ai), while Tubingen larvae tended to produce long latency ‘LLC’ responses (Aii). In contrast, the inhibitory effect of a weak prepulse (PPI) was similar in both groups (C), making these strains compatible for genetic screening purposes. All graphs show mean ± SEM (p < 0.01).