Table 4.

Least square means of symptom severity at the first intervention contact by age and trial arm adjusted for symptom severity at intake interview and the number of days between intake interview and first intervention contact.

Symptom	Age	Nurse Arm	AVR Arm	P-value for Arm Comparison	Between Arm Effect Size
		Mean (St Error)	Mean (St Error)
Alopecia	25 – 44	2.19 (0.72)	3.46 (0.68)	0.13	0.35†
	45 – 74	1.75 (0.30)	3.23 (0.29)	<0.01**	0.45†
	75 +	0.28 (0.51)	1.70 (0.55)	<0.01	0.67†
Poor Appetite	25 – 44	1.49 (0.39)	1.85 (0.37)	0.47	0.11
	45 – 74	1.74 (0.23)	2.68 (0.21)	<0.01**	0.31
	75 +	2.40 (0.43)	1.67 (0.46)	0.30	-0.24
Constipation	25 – 44	1.09 (0.35)	1.58 (0.34)	0.27	0.20
	45 – 74	1.04 (0.19)	2.02 (0.17)	<0.01**	0.34†
	75 +	0.76 (0.38)	1.29 (0.40)	0.27	0.18
Cough	25 – 44	0.75 (0.20)	0.69 (0.19)	0.81	-0.03
	45 – 74	0.98 (0.12)	1.20 (0.11)	0.16	0.10
	75 +	0.96 (0.22)	0.57 (0.24)	0.28	-0.17
Diarrhea	25 – 44	0.80 (0.16)	0.37 (0.16)	0.09	-0.17
	45 – 74	0.50 (0.10)	0.94 (0.10)	<0.01**	0.18
	75 +	0.31 (0.26)	0.85 (0.28)	0.09	0.19
Dry Mouth	25 – 44	1.97 (0.38)	1.72 (0.36)	0.65	-0.10
	45 – 74	1.81 (0.16)	1.57 (0.15)	0.29	-0.08
	75 +	1.63 (0.40)	1.51 (0.44)	0.84	-0.05
Dyspnea	25 – 44	0.55 (0.32)	1.55 (0.30)	<0.01**	0.42†
	45 – 74	0.86 (0.12)	1.20 (0.11)	0.03	0.13
	75 +	1.82 (0.25)	0.78 (0.28)	0.03	-0.49†
Fatigue	25 – 44	3.44 (0.49)	3.77 (0.47)	0.62	0.12
	45 – 74	3.37 (0.24)	4.22 (0.23)	<0.01*	0.32
	75 +	4.72 (0.55)	3.53 (0.59)	0.19	-0.39†
Nausea/Vomiting	25 – 44	0.99 (0.31)	1.37 (0.30)	0.33	0.14
	45 – 74	0.65 (0.14)	1.42 (0.13)	<0.01**	0.27
	75 +	0.56 (0.28)	0.83 (0.30)	0.48	0.13
Pain	25 – 44	2.29 (0.38)	1.28 (0.30)	0.08	-0.38†
	45 – 74	1.18 (0.27)	2.54 (0.21)	<0.01**	0.48†
	75 +	2.62 (0.42)	1.24 (0.39)	0.06	-0.55†
Peripheral Neuropathy	25 – 44	1.17 (0.26)	1.20 (0.25)	0.94	0.01
	45 – 74	0.78 (0.12)	1.23 (0.11)	<0.01**	0.17
	75 +	1.81 (0.32)	1.33 (0.35)	0.36	-0.35†
Difficulty Remembering	25 – 44	1.89 (0.29)	1.32 (0.27)	0.20	-0.22
	45 – 74	1.47 (0.13)	1.35 (0.12)	0.51	-0.05
	75 +	0.89 (0.29)	1.00 (0.31)	0.80	0.05
Insomnia	25 – 44	2.74 (0.56)	2.94 (0.52)	0.78	0.06
	45 – 74	2.05 (0.21)	2.36 (0.20)	0.27	0.10
	75 +	3.90 (0.41)	1.52 (0.46)	<0.01*	-0.81†
Weakness	25 – 44	1.81 (0.43)	2.14 (0.40)	0.55	0.13
	45 – 74	2.04 (0.21)	2.39 (0.19)	0.20	0.12
	75 +	1.75 (0.49)	2.14 (0.53)	0.57	0.12

^*Statistically significant according to Benjamini-Hochberg procedure

^**Statistically significant according to Bonferroni procedure (all comparisons that are significant with Bonferroni procedure are also significant with Benjamini-Hochberg procedure)

^†Effect sizes exceeding .33 deemed clinically significant