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. 2000 Nov 21;97(24):13342–13347. doi: 10.1073/pnas.97.24.13342

Figure 1.

Figure 1

Characteristics of LTD evoked with a stimulus of 1 Hz for 15 min at the Schaffer collateral–CA1 synapses. Shown are the time courses of % changes in field EPSP slopes. (a) Prolonged 1-Hz stimulation for 15 min resulted in a significant long-lasting depression (n = 12). Labeled 1-Hz bar indicates interval of stimulation. (Inset) Representative EPSP traces recorded before and 1 h subsequent to the depression protocol. (The same succession of traces is shown for each experiment. Calibration bars for each experiment are 0.5 mV, 5 ms.) (b) LTD was elicited with 1-Hz stimulation. After 2 h of depression, theta burst stimulation (TTB) was applied. LTD was completely reversed and LTP was induced (n = 4). (c) Application of the NMDA antagonist APV (50 μM) (labeled horizontal bar) blocked induction of LTD. After washout of APV, LTD was elicited with 1-Hz stimulation (n = 5). (d) Two independent inputs to the same population of postsynaptic cells were stimulated in an alternating manner. Only one pathway received the depression protocol. LTD was induced only in the synapses that received the depression protocol (n = 7).