Figure 3.

Characteristics of LTD evoked with a stimulus of 5 Hz for 3 min. (a) A weak stimulation protocol of 5 Hz for 3 min elicited a more attenuated short-term depression (E-LTD) that returned to baseline for time points later than 30 min (n = 10). (b) E-LTD was elicited with 5-Hz stimulation. Subsequent delivery of 1-Hz stimulation to the same synapses led to an enduring L-LTD (n = 4). (c) The NMDA antagonist APV was applied (labeled horizontal bar) and blocked the induction of LTD. After washout of APV, LTD was elicited with 5-Hz stimulation (n = 7).