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. 2000 Nov 21;97(24):13342–13347. doi: 10.1073/pnas.97.24.13342

Figure 4.

Figure 4

The late protein synthesis component of LTD can be captured by another input. (a) L−LTD was induced in one pathway with 1-Hz stimulation. After 30 min, anisomycin was applied (for a total of 45 min) and the second pathway received the depression protocol in the presence of anisomycin. Despite the inhibition of protein synthesis, the second pathway exhibited L-LTD (n = 5). (b) The L-LTD exhibited by the second pathway in a was significantly different from the LTD observed during the inhibition of protein synthesis in the one-pathway experiments described in Fig. 2a (P < 0.05, measured 1 h after the stimulus delivered in the presence of anisomycin). (c) L-LTD was elicited in one pathway with 1-Hz stimulation. After 30 min, E-LTD was elicited in the second pathway with the weaker 5-Hz stimulation. E-LTD in the second pathway was transformed into prolonged L-LTD (n = 7; P < 0.001, as compared with 5-Hz stimulation alone).