Table 2.
Summary of analyses of RCC10 and 786-O cell lines.
| Cell Line | Subtype | Epithelial Morphologya | VHL Instability | Aberrant ZO-1 | |
|---|---|---|---|---|---|
| RCC10 | 786-O | ||||
| Wild-type | - | + | + | - | - |
| control | 1 | - | - | +++ | |
| del 114–178 | 1 | - | - | +b | ++ |
| RC161/2QW | 1 | - | - | +b | +++ |
| S65W | 1 | - | N/D | + | ++ |
| N78S | 1 | - | N/D | + | ++ |
| L158P | 1 | - | N/D | + | +++ |
| L188Q | 1 | +/- | + | + | +++ |
| Y98H | 2A | + | + | - | - |
| Y112H | 2A | + | + | - | N/D |
| Y98N | 2B | + | + | +/- | + |
| Y112N | 2B | + | + | - | N/D |
| R167Q | 2B | + | +/- | + | ++ |
| R167W | 2B | + | + | +b | N/D |
| V84L | 2C | + | + | N/D | N/D |
| L188V | 2C | + | + | - | - |
a – indicates a disorganized fibroblast-like morphology
+/- indicates that an intermediate morphology was observed
b previously demonstrated in [53]
N/D = not determined