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. Author manuscript; available in PMC: 2010 Feb 7.
Published in final edited form as: Oncogene. 2009 Jun 15;28(31):2773–2783. doi: 10.1038/onc.2009.135

Figure 1.

Figure 1

A. Survey of major known mutations in 199 lung adenocarcinomas. EGFR, KRAS, BRAF, and ERBB2 mutations are mutually exclusive. Mutant samples (columns) are sorted by grouped mutations per one-way average-linkage hierarchical clustering on binary data. Black represents samples with single mutations, while red are samples harboring mutations in more than one gene. Sample numbers are indicated at left, 140 cases harbored at least one mutation. Samples without detected mutations in these genes are not shown. B. Recurrent genomic copy number alterations in 199 lung adenocarcinomas. Frequency of gain (red) and loss (blue) is shown by genomic position across the 22 autosomes. Centromeres are identified by dotted vertical lines; acrocentric p-arms and loci lacking array coverage are indicated as gaps. The most prevalent losses are at 8p and 9p21; among gains, 1q, 5p, and 8q are most frequent.