Table 1.
EGFR and KRAS expression profiles. Top 25 genes shown; complete lists provided in Supplementary Table 5.
| Genes differentially expressed in EGFR mutant versus wild type tumors | Genes differentially expressed in KRAS mutant versus wild type tumors | ||||||
|---|---|---|---|---|---|---|---|
| Symbol | Cytoband | SWS | P-value | Symbol | Cytoband | SWS | P-value |
| DUSP4* | 8p12-p11 | -6.7 | 2.4E-11 | MCL1* | 1q21 | 5.1 | 3.3E-07 |
| EGFR* | 7p12 | 6.4 | 1.4E-10 | IGF2BP3* | 7p11 | -5.0 | 5.2E-07 |
| PRDM4* | 12q23-q24.1 | -6.4 | 1.8E-10 | KRAS* | 12p12.1 | 5.0 | 7.1E-07 |
| TXNRD1 | 12q23-q24.1 | -6.0 | 1.5E-09 | PRNPIP | 1p32 | -4.9 | 8.0E-07 |
| GTF2E2 | 8p21-p12 | -6.0 | 1.6E-09 | FTSJ2 | 7p22 | -4.9 | 8.3E-07 |
| GPR177 | 1p31.3 | 6.0 | 1.8E-09 | SNRPD3 | 22q11.23 | -4.8 | 2.0E-06 |
| MGC13098* | 7p13 | 6.0 | 2.0E-09 | KIAA1033 | 12q24.11 | 4.7 | 2.8E-06 |
| GALNT10* | 5q33.2 | 5.9 | 3.5E-09 | RHOB | 2p24 | 4.7 | 2.9E-06 |
| LRRC31 | 3q26.2 | 5.8 | 5.0E-09 | MED18 | 1p35.3 | -4.6 | 3.6E-06 |
| KIAA0319L | 1p34.2 | 5.8 | 7.9E-09 | PAC 886K2 | 1p36.11 | -4.5 | 7.3E-06 |
| MKL2 | 16p13.12 | 5.8 | 8.8E-09 | LANCL2 | 7q31.1-q31.33 | -4.5 | 8.1E-06 |
| RAD51L1 | 14q23-q24.2 | 5.7 | 1.2E-08 | USP2 | 11q23.3 | -4.5 | 8.4E-06 |
| KIAA0495 | 1p36.32 | 5.7 | 1.3E-08 | FOXRED2 | 22q12.3 | -4.4 | 1.3E-05 |
| RHCE | 1p36.11 | 5.7 | 1.4E-08 | RPL13A | 19q13.3 | 4.3 | 1.5E-05 |
| HIP1 | 7q11.23 | 5.6 | 1.7E-08 | SMPDL3A | 6q22.31 | 4.3 | 1.6E-05 |
| GPR172B | 17p13.2 | 5.6 | 2.2E-08 | STK24 | 13q31.2-q32.3 | 4.3 | 1.6E-05 |
| TNFRSF10B | 8p22-p21 | -5.6 | 2.5E-08 | MAFF | 22q13.1 | 4.3 | 1.7E-05 |
| C16orf58* | 16p11.2 | 5.5 | 3.2E-08 | NXPH4 | 12q13.3 | -4.3 | 1.8E-05 |
| RNF40 | 16p11.2-p11.1 | 5.5 | 3.2E-08 | C7orf30 | 7p15.3 | -4.3 | 2.0E-05 |
| MYST1 | 16p11.2 | 5.5 | 4.0E-08 | LOC81691 | 16p12.2 | -4.3 | 2.0E-05 |
| ADCY9 | 16p13.3 | 5.4 | 6.1E-08 | SNHG3-RCC1 | 1p36.1 | -4.3 | 2.0E-05 |
| LRRC47 | 1p36.32 | 5.4 | 6.8E-08 | TRMT5 | 14q23.1 | -4.3 | 2.0E-05 |
| KYNU | 2q22.2 | -5.4 | 7.5E-08 | PPIE | 1p32 | -4.2 | 2.1E-05 |
| RFK | 9q21.13 | -5.4 | 8.2E-08 | IVNS1ABP | 1q25.1-q31.1 | 4.2 | 2.2E-05 |
| HLA-DMA | 6p21.3 | 5.3 | 9.7E-08 | DUSP6 | 12q22-q23 | 4.2 | 2.3E-05 |
Note: for genes that were represented on these lists of the top 25 genes by more than one Affymetrix probe set (indicated by *), only the top scoring probe set is shown; SWS = stratified Wilcoxon statistic with the sign of the statistic indicating either over- or under-expression; two-sided p-values calculated from a normal distribution; PAC886K2 indicates genomic clone containing EST corresponding to Affymetrix probe set 213685_at.