Table 2. Replication testing for 11 top GWAS SNPs in an independent study of case–parent trios of Mexican ethnicity.

SNPa	Chr	SNP type	Geneb	Minor allele	GWAS (N = 492 trios)					Replication study (N = 177 trios)
					MAF	RRc	Lower CI	Upper CI	Log-linear p-value	MAF	RRc	Lower CI	Upper CI	Log-linear p-value
rs1867612	16	Intergenic	(GOT2, CDH8)	A	0.08	0.44	0.31	0.63	1.55×10−6	0.11	1.11	0.68	1.84	0.67
rs2247572	8	Intronic	KCNB2	T	0.15	1.88	1.45	2.44	1.94×10−6	0.16	1.27	0.84	1.89	0.26
rs6063725	20	Intergenic	(SALL4, ZFP64)	C	0.34	1.56	1.30	1.89	3.52×10−6	0.38	1.15	0.86	1.56	0.35
rs720810	20	Intergenic	(SALL4, ZFP64)	G	0.26	1.61	1.32	2.00	5.13×10−6	0.32	1.16	0.85	1.61	0.34
rs2378383	9	Intergenic	(CHCHD9, TLE4)	G	0.22	0.61	0.49	0.76	7.10×10−6	0.20	0.63	0.41	0.96	0.030
rs6951506	7	Intronic	DOCK4	A	0.20	0.60	0.47	0.76	1.10×10−5	0.24	0.88	0.62	1.26	0.50
rs3734083	5	Intronic	GALNT10	T	0.18	1.68	1.33	2.13	1.21×10−5	0.19	0.72	0.48	1.07	0.10
rs2378377	9	Intergenic	(CHCHD9, TLE4)	G	0.28	0.64	0.53	0.79	1.36×10−5	0.28	0.71	0.50	1.02	0.061
rs4674039	2	Intergenic	(FN1, MREG)	C	0.42	0.67	0.56	0.81	1.51×10−5	0.49	1.11	0.82	1.51	0.50
rs1830206	10	Intergenic	(FZD8, ANKRD30A)	G	0.26	1.55	1.27	1.89	2.17×10−5	0.25	1.20	0.85	1.71	0.30
rs3814593	10	Intronic	PITRM1	T	0.32	0.67	0.55	0.81	3.30×10−5	0.35	0.82	0.58	1.15	0.24

^aSNPs are ranked from smallest to largest GWAS p-value.

^bGene names are listed for SNPs mapping within genes. For intergenic SNPs, the nearest genes (upstream, downstream) are listed.

^cRelative risk for carrying one copy of the minor allele compared to carrying no copies.