Fig. 1.

CML and pentosidine are elevated in AMD plasma. CML (A) and pentosidine concentrations (B) quantified by LC-MS/MS and LC-fluorometry from control (n = 32) and AMD (n = 58) plasma donors and autoantibody titers for CML (C) and pentosidine (D) quantified by ELISA (32 control and 57 AMD plasma samples) are shown with median (○) results ±first and third quartiles (Q1, Q3) and mean (△) results ±S.D. p values (two-sided t test) were determined from log-transformed concentrations. Correlation between CML and pentosidine concentrations is shown for the control (E) and AMD (F) cohorts with horizontal and vertical dashed lines indicating median control values. Significantly more donors with both CML and pentosidine elevated are apparent in AMD patients than in the controls (upper right quadrants in E and F).