Table 2. Grade 3/4 Toxicity -Pre-operative Treatment Only.
| Grade 3 | Grade 4 | |||
|---|---|---|---|---|
| Hematologic | D | DB | D | DB |
| Leukocytopenia | 2 | 1 | ||
| Infection without neutropenia | 1 | 1 | ||
| Neutropenia | 1 | 1 | ||
| Anemia | 2 | |||
| Non-Hematologic | ||||
| Metabolic* | 3 | 1 | ||
| Hyperglycemia | 2 | 1 | ||
| Elevated transaminases | 1 | 1 | 1 | |
| Stomatitis | 4 | |||
| Anorexia/fatigue | 2 | 3 | ||
| Abdominal pain/nausea/vomiting/dehydration | 3 | 3 | ||
| Eye tearing | 1 | |||
| Sensory neuropathy | 1 | |||
| Myalgia | 1 | |||
| Melena/GI bleed | 1 | |||
| Perforated viscous** | 1 | |||
| Total | 10 | 23 | 4 | 2 |
D-docetaxel; DB-docetaxel and bevacizumab
*
Hypophosphatemia,hypouricemia,hyponatremia,hypokalemia
**
One treatment-related death No episodes of uncontrolled hypertension or proteinuria