Table III.
Association of VDR haplotypes and colon cancer riska
| Frequency in cases/controls | Crude OR (95% CI) | Adjusted OR (95% CI) | |
| Cdx-2–FokI | |||
| G-C | 0.43/0.49 | 1.0 (reference) | 1.0 (reference) |
| G-T | 0.31/0.31 | 1.16 (0.84–1.60) | 1.16 (0.82–1.64) |
| A-C | 0.15/0.13 | 1.38 (0.88–2.17) | 1.07 (0.64–1.78) |
| A-T | 0.10/0.08 | 1.51 (0.90–2.54) | 1.97 (1.06–3.67) |
| Cdx-2–TaqI | |||
| G-A | 0.45/0.54 | 1.0 (reference) | 1.0 (reference) |
| G-G | 0.28/0.26 | 1.30 (0.95–1.78) | 1.43 (0.99–2.05) |
| A-A | 0.12/0.09 | 1.58 (0.96–2.60) | 1.69 (0.98–2.89) |
| A-G | 0.14/0.11 | 1.40 (0.94–2.11) | 1.27 (0.81–2.00) |
| FokI–TaqI | |||
| C-A | 0.33/0.37 | 1.0 (reference) | 1.0 (reference) |
| C-G | 0.25/0.24 | 1.12 (0.75–1.67) | 1.19 (0.73–1.93) |
| T-A | 0.24/0.26 | 1.04 (0.72–1.51) | 1.21 (0.78–1.88) |
| T-G | 0.17/0.13 | 1.51 (0.99–2.30) | 1.68 (1.04–2.71) |
| Cdx-2–FokI–TaqI | |||
| G-C-A | 0.26/0.31 | 1.0 (reference) | 1.0 (reference) |
| G-C-G | 0.17/0.18 | 1.15 (0.70–1.88) | 1.67 (0.91–3.07) |
| G-T-A | 0.20/0.23 | 1.06 (0.67–1.67) | 1.27 (0.76–2.14) |
| G-T-G | 0.11/0.08 | 1.73 (0.97–3.08) | 1.50 (0.81–2.75) |
| A-C-A | 0.07/0.06 | 1.60 (0.74–3.44) | 1.84 (0.77–4.43) |
| A-C-G | 0.08/0.07 | 1.40 (0.67–2.91) | 0.85 (0.39–1.83) |
| A-T-A | 0.05/0.03 | 1.61 (0.69–3.76) | 1.96 (0.71–5.41) |
| A-T-G | 0.06/0.04 | 1.51 (0.66–3.47) | 3.63 (1.01–13.07) |
a
Adjusted for age, sex, non-steroidal inflammatory drug use, BMI and family history of colorectal cancer.