Table VI.
Group | Total number of risk genotypes | Controls | % | Cases | % | OR (95% CI)a | P-value |
Caucasianb | 0–1 | 111 | 29.4 | 53 | 17.8 | Referent | |
2 | 182 | 48.3 | 153 | 51.3 | 1.73 (1.16, 2.58) | 0.007 | |
3 | 77 | 20.4 | 83 | 27.9 | 2.36 (1.48, 3.75) | <0.001 | |
4 | 7 | 1.9 | 9 | 3.0 | 3.08 (1.05, 8.99) | <0.001 | |
Ptrend <0.001 | |||||||
African-Americanc | 0 | 24 | 35.8 | 9 | 17.6 | Referent | |
1 | 34 | 50.7 | 26 | 51.0 | 2.27 (0.83, 6.24) | ||
2+ | 9 | 13.4 | 16 | 31.4 | 6.27 (1.71, 22.92) | 0.006 | |
Ptrend = 0.006 |
Adjusted for age, FH of breast cancer, smoking history, age at menarche, age at first live birth and BMI.
In Caucasians, risk genotypes ADPRT 762VV (rs1136410), APE1 148DD (rs3136820), ERCC4 415RQ/QQ (rs1800067) and MLH1 219II/IV (rs1799977) were included in the model.
In African-Americans, risk genotypes ADPRT 762VA (rs1136410), ERCC2 751KQ/QQ (rs13181) and NBS1 185EQ/QQ (rs1805794) were included in the model.