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. 2008 May 20;17(16):2552–2569. doi: 10.1093/hmg/ddn156

Figure 8.

Figure 8.

Motor neuron and motor axon loss in SMA mice. (A) Quantification of myelinated axons in C4-dorsal roots (C4-d), C4-ventral roots (C4-v), PN (phrenic nerves), and L4-ventral roots (L4-v) in P14 Δ7+/+ SMA (S) mice and age-matched Controls (C). Data represented as mean ± SD (n = 3). ‘Asterisk' denotes P < 0.01 (Student's t-test). n.s.: not significant. (B) Transverse sections through the C4 and L4 roots and phrenic nerve from a P14 Δ7+/+ SMA mouse and a Control (Ctrl) indicating selective loss and atrophy of axons in the C4 root and phrenic nerve. Axons in the caudally located L4 root are spared. Scale bar: 100 µm. (C, D) Graphs indicating loss of large caliber axons in the C4 root and phrenic nerve in P14 Δ7+/+ SMA mice. (E) Motor neuron cell body counts indicate a selective and significant loss (∼30%) in the rostral but not caudal spinal cords of P14 Δ7+/+ SMA (S) mice; Controls (C). ‘Asterisk' denotes P < 0.01 (Student's t-test); n = 3. n.s.: not significant.