Figure 2.

Clearance of aggresome-like inclusions by autophagy is not a universal phenomenon. (A) Bar graph showing the relative fold difference in the number of inclusions observed in SH-SY5Y cells ectopically expressing various aggregation-prone proteins (as indicated) under different recovery conditions. (B) Bar graph showing the relative fold difference in the number of inclusions observed in wild-type (WT) or autophagy-deficient ATG5−/− mouse embryonic fibroblasts ectopically expressing various aggregation-prone proteins (as indicated) recovering under normal or starved conditions. Each of these experiments was repeated at least three times (*P < 0.05, **P < 0.01, ***P < 0.001 versus control group).