Figure 4.

The GluR1 C terminus is not cleaved in CA1 after global ischemia. The ratio of GluR1 subunit abundance in CA1 (Left) and CA3-DG (Right) calculated from Westerns probed with GluR1_C Ab or GluR1_N Ab. Protein samples were from control animals and experimental animals at 48, 60, and 72 h after ischemia. In CA1 and CA3-DG, the GluR1_c/GluR1_N ratio was not significantly changed at any times examined after ischemia, indicating stability of the GluR1 C terminus after ischemia. Band densities were corrected for protein concentration and normalized to corresponding control values. Bars are means ± SEMs from four experiments.