Table 1.

Relative biases (%) and relative root mean square errors (RMSE) (%) of the estimated parameters evaluated by the extended SAEM algorithm and the FOCE algorithm (nlme function) from 1000 simulated trials.

	n=24 subjects				n=40 subjects
	Bias		RMSE		Bias		RMSE
	SAEM	nlme	SAEM	nlme	SAEM	nlme	SAEM	nlme
V	0.01	0.53	3.9	6.4	−0.06	0.54	2.91	5.00
ka	0.48	−1.48	14.4	24.4	0.02	−3.07	10.79	18.4
AUC	−0.08	−0.20	1.0	1.5	−0.11	−0.24	0.79	1.13
βV	−0.00	−0.01	3.6	3.6	−0.05	−0.06	2.83	2.80
βka	−0.73	−0.76	14.2	18.8	0.24	0.27	10.73	10.60
βAUC	0.02	−0.02	0.7	1.1	0.00	1.14	0.57	1.14
${\omega }_V^2$	−5.13	−5.92	38.7	38.4	−3.45	−4.28	30.30	30.37
${\omega }_{k_a}^2$	−3.99	−7.07	42.4	41.5	−3.23	−4.63	33.49	33.32
${\omega }_{\mathit{AUC}}^2$	−4.88	−7.29	34.5	34.2	−1.51	−3.80	27.41	27.02
${\psi }_V^2$	−8.67	−7.29	69.4	68.5	−5.93	−4.91	58.78	57.81
${\psi }_{k_a}^2$	−10.94	−9.09	73.5	72.0	−7.06	−5.17	62.00	60.60
${\psi }_{\mathit{AUC}}^2$	−5.37	−5.37	43.6	42.6	−4.92	−5.79	33.31	32.47
σ2	−0.33	−0.10	7.7	7.7	0.28	0.67	6.03	6.09