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Inhibition of PKA by H-89. PKA present at 2 μM, Kemptide at 1 mM, ATP at the concentration indicated.
| 2.5 mM ATP | 5 mM ATP | |||
|---|---|---|---|---|
| [H-89] (μM) | kcat (s−1) | KM (μM) | kcat (s−1) | KM (μM) |
| 0 | 7 ±0.3 | 19 ±5 | 8.5 ±0.4 | 16 ±4 |
| 2.5 | 5.3 ±1.2 | 18 ±5 | 6.4 ±1.2 | 14 ±0.2 |
| 5 | 4.4 ±1.2 | 17 ±10 | 7.4 ±1.2 | 20 ±5 |
| 25 | 3.1 ±0.2 | 21 ±8 | 7.3 ±0.5 | 15 ±0.5 |
