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. 2009 Jun 4;18(17):3266–3273. doi: 10.1093/hmg/ddp264

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Structure of TauPTM6 and TauPTM9 and resulting trans-spliced products. The coding sequence of TauPTM6 and TauPTM9 consists of exons 10–13 or exons 11–13, respectively, followed by a 24 nt FLAG epitope sequence. The trans-splicing domain of the PTMs comprises a 125 nt binding domain (BD) complementary to the 3′ end of tau intron 9 as well as a strong conserved yeast branch point sequence (BP), a 26 nt polypyrimidine tract (PPT), an AG acceptor site and a spacer sequence separating the binding domain and the branch point. Arrows indicate the locations of the PCR primers used to detect cis- and trans-splicing events.