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. Author manuscript; available in PMC: 2009 Aug 7.
Published in final edited form as: J Magn Reson Imaging. 2009 May;29(5):997–1007. doi: 10.1002/jmri.21731

FIG 6.

FIG 6

Transmission electron microscope images of plaques in (a) APP/PS1 and (b) human AD tissue. The 6000× magnification images of the plaques include the whole plaque within the imaging plane. The plaque diameter for both APP/PS1 and AD tissue is approximately the same, at 10 µm. The lower magnification image illustrates the denser overall structure of the beta-amyloid plaques in the APP/PS1 compared to the human AD tissue. The human AD plaques have numerous gaps present between the fibril bundles throughout them that are rarely found in the transgenic mouse plaques. 46,000× magnification of the outlined regions reveal differences in the fibrillar orientation of the beta-amyloid strands in the APP/PS1 and AD plaques. Magnification of the outlined regions also illustrates the denser nature of the APP/PS1 plaques while the human AD tissue has gaps between amyloid strand clusters.