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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cell Metab. 2009 Aug;10(2):89–98. doi: 10.1016/j.cmet.2009.06.011

Figure 1. LepRbEGFP mice reveal a large population of leptin-responsive LHA LepRb neurons.

Figure 1

(A) Schematic diagram demonstrating cre-mediated EGFP expression in LepRb expressing cells of LepRbEGFP mice. (B) Immunofluorescent detection of EGFP (green) in the LHA of LepRbEGFP mice. (C,D) Immunohistochemical detection of pSTAT3-IR (red nuclei) and EGFP (green) in the LHA of LepRbEGFP mice following IP treatment with vehicle (C) or leptin (5 mg/kg, 2 hours) (D). Insets: higher magnification view of labeled LHA neurons. Scale bars = 10 µm. 3V= third cerebral ventricle; MT= mammilothalamic tract; f= fornix.