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14-3-3σ negatively interferes with melanoma cell migration. Stably transfected SK-Mel-147 melanoma cells with respective empty control vector, 14-3-3σ cDNA and 14-3-3σ shRNA (si14-3-3B4), respectively, were used to test the influence of 14-3-3σ on melanoma cell migration. A wounding assay was performed and wound closure was analyzed after 24 h. For inhibition of cell proliferation 10 μg/ml mitomycin C was added 3 h before wounding of the cell layer.
