Figure 2.

Absence of paired-pulse depression in PV−/− mice. (A) Superimposed IPSCs recorded in a Purkinje cell of a PV+/+ mouse after double extracellular stimulations of GABAergic interneurons (30ms ISI, dotted traces), and average response for the entire experiment (solid trace). (B) Representative results from a similar experiment performed with a PV−/− mouse. (C) Average PPR as a function of ISI in PV+/+ mice (circles, n = 12) and PV−/− mice (diamonds, n = 19). Note that, in this figure and in the following ones, failures are included in the calculation of mean traces.