Skip to main content
. 2000 Nov 7;97(24):13372–13377. doi: 10.1073/pnas.230362997

Figure 3.

Figure 3

Paired-pulse depression can be rescued in PV−/− mice by EGTA. (A) Superimposed IPSCs recorded in a Purkinje cell (dotted traces, post) of a PV−/− mouse after induction of two action potentials in a presynaptic interneuron by depolarizing steps (30 ms ISI) and average response for the entire experiment (solid trace). The interneuron was recorded with a solution containing 50 μM EGTA. (B) Representative results from a similar experiment where the interneuron was recorded with a solution containing 1 mM EGTA. (C) Average PPR as a function of ISI in PV−/− mice in conditions where interneurons were extracellularly stimulated (open diamonds, same data as in Fig. 2C), or were recorded with a solution containing 50 μM EGTA (filled squares, n = 13), or were recorded with a solution containing 1 mM EGTA (filled diamonds, n = 11).